
- Charlton turned down the role of "Police Chief Brody" in Jaws. The role eventually went to Roy Scheider.
- Charlton was hired by the F.B.I during the April 1993 Waco stand-off with cult leader David Koresh, to play the voice of God while communicating with him. However the plan was never used.
- The American Film Institute has honoured Charlton with an award named after him, which he was the first recipient.
- Charlton was interviewed in the 2003 documentary Bowling for Columbine, by Michael Moore. Charlton however walked out during the interview when he realized Michael was criticizing his for his involvement with the N.R.A.
- He was elected president of the Screen Actors Guild six times.
- After his starring role in the 1968 version of Planet of the Apes, he had an uncredited cameo in the 2001 remake, as General Thade's dying father.
- His professional name of Charlton Heston came from a combination of his mother's maiden name (Lila Charlton) and his stepfather's last name (Chester Heston).
- His daughter Holly is adopted.
- His nickname is 'Chuck'.
- He attended Northwestern University in Evanston, Illinois.